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From a central perspective, magnetic resonance spectroscopy studies have demonstrated that prefrontal cortex GABA concentration decreases by 1822% in depression patients, which was significantly and positively correlated to gut GABA-producing microbial abundance ( Probiotic intervention studies have provided direct evidence for the causal role of the GABA pathway in comorbidity

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Wang C, Xia Y, Zheng Y, Dai W, Wang F, Chen K, Li J, Li S, Zhu R, Yang J, Yin Q, Zhang H, Wang J, Lu J, Zhou Y, Guo C (2015) Protective effects of N-acetylcysteine in concanavalin A-induced hepatitis in mice