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A placebo-controlled RCT investigated TAK-071 , a muscarinic acetylcholine M1 PAM, as a treatment to improve gait function in 54 participants with PD with cognitive impairment assessed a cognitive composite score as a secondary endpoint and found a significant improvement [163]

Senolytic therapies targeting anti-apoptotic pathways can eliminate senescent cells and enhance chemoradiotherapy efficacy of cancer 10,32

Taksima T, Chonpathompikunlert P, Sroyraya M, Hutamekalin P, Limpawattana M, Klaypradit W (2019) Effects of astaxanthin from shrimp shell on oxidative stress and behavior in animal model of Alzheimers disease

It also combats free radicals that lead to ageing and skin damage

Rawlins et al., 2009)

Konturek SJ, Brzozowski T