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In tirzepatide trials, reductions were often larger, with some analyses showing average decreases of 25 to 30% or more at higher doses
doi: 10.1007/s10725-005-0002-2
For suspected macro-B12, precipitation with PEG is the test most often reached for, though it is nonspecific and can remove B12 that is fully available to cells, so direct measurement of the binding proteins, haptocorrin and transcobalamin, may be more informative when it is available
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