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Adegbesan BO, Adenuga GA

Paromomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycinsusceptibleresistant Leishmania donovani

This will diminish over time and can be controlled with other treatments

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Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events