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Protein binding of valproate is reduced in the elderly, in patients with chronic hepatic diseases, in patients with renal impairment, and in the presence of other drugs (e.g., aspirin)

The SELECT cardiovascular outcomes trial, whose results were fully incorporated into regulatory labeling by 2024, directly catalyzed a new wave of prescribing for semaglutide in cardiology settings, materially broadening the addressable API volume requirement