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Monitoring schedule Healthcare providers who specialize in GLP-1 therapy typically recommend this monitoring cadence: Baseline: Full B12 panel before starting semaglutide 3 months: Repeat serum B12 and MMA 6 months: Full panel reassessment Annually: Once stable, annual monitoring is usually sufficient For high-risk patients (metformin users, vegans, those over 60, post-bariatric surgery), the 3-month check is particularly important

Many individuals schedule B12 shots periodically based on provider recommendations

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This nerve damage may result from diabetes, vitamin deficiencies, autoimmune disease, chemotherapy, alcohol or drug misuse, and other causes

PMID 13374343