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Because it circulates systemically, it can act on every active injury site at once

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Inflammatory cytokines contribute to brain endothelial cell activation and downregulation of tight junction proteins, such as zonula occludens-1 and claudin-5, resulting in bloodbrain barrier dysfunction [55]

doi: 10.1097/FJC.0000000000000864 [DOI] [PubMed] [Google Scholar] 188.Arnold SV, de Lemos JA, Rosenson RS, et al

Similar mechanisms operate in horticultural and fruit crops: in tomato ( Solanum lycopersicum ), drought increases ABA levels, activating ABA-responsive transcription factors and oxidative stress pathways