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In adults with obesity, without type 2 diabetes, weight loss is typically about 15-16 percent of starting body weight over the course of a year with Wegovy, Maselli says

Glucagon-Like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes

PMID: 12475787

Here is a quick breakdown of where the key next-generation candidates currently stand: Retatrutide (Eli Lilly): Phase 3 trials are actively studying cardiovascular outcomes alongside weight loss

doi: 10.1111/bcpt.13427

Understanding retatrutide dosing is critical because the dose escalation schedule matters significantly for both results and tolerability