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Similarly, IL-1-induced BMSC-Exos reversed hemin-induced ferroptosis in neuronal cells, including high iron, ROS, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and reduced GSH level and cell viability [143]

FIGURE 3 5 Mechanistic differences of ferroptosis in normal and cancerous tissues Ferroptosis, an iron-dependent lipid peroxidation-driven form of cell death, exhibits significant differences in its mechanisms between normal and cancerous tissues (Jiang X