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In addition, Nic-FMT led to decreased levels of TC and TG in the liver and peripheral circulation (Figures 3IL), as well as LDL-c levels in serum (Supplementary Figure 4D), although HDL-c levels did not change significantly (Supplementary Figure 4E)

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Attractively, even though it is the main receptors expressed in neutrophils, the P2Y2 receptor is barely involved in NETs generation due to the finding that the P2Y2 receptor antagonist called AR-C25118925XX had no influence on NETs release

The mevalonate pathway includes the production of isopentenyl pyrophosphate, squalene, coenzyme Q10, and cholesterol, which affect ferroptosis