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126 The PI3K/Akt pathway is pivotal, where insulin activation phosphorylates phosphatidylinositol 4,5-bisphosphate via PI3K to produce phosphatidylinositol 3,4,5-triphosphate, triggering Akt

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The medication's stimulatory effect on metabolism may also increase baseline energy levels, making it harder to reach restful sleep in the first few days or weeks of treatment

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Trulicity is also approved to lower the risk of major cardiovascular events such as heart attack or stroke in adults with type 2 diabetes and heart disease