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Longo JF, Weber SM, Turner-Ivey BP, Carroll SL

Over 100 years ago, physicians experimented with TPEs potential to increase lifespan when the first recorded plasma exchange procedure was performed on animals

This selectivity means fewer side effects compared to older GH secretagogues like GHRP-6 (which increases appetite) or GHRP-2 (which can elevate cortisol)

Subcutaneous injection near the abdomen targets gut-related effects more directly, while oral peptide capsules offer an alternative delivery method that directly contacts the GI mucosa

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My physician claims that it was due to nerve irritation from the injections