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3) Transcriptomic signatures of oocyte developmental competence The oocyte transcriptome encodes both developmental history and future competence, reflecting the integrity of maternal programs that sustain early embryogenesis before zygotic genome activation [4, 94, 95]

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However, before they can be deployed, they have to be purified from cell lysates, cell culture supernatants, or biological probes

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Supplementary Video 3 (download MOV Example of cells undergoing mitosis in the basal layer of H2BGFP-expressing esophageal epithelioids (Methods) imaged by confocal live imaging