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That decline is part of why it's drawn research interest in the first place: if a molecule occurs naturally and its levels drop as tissue repair capacity drops, it becomes a reasonable candidate for studying repair signaling directly

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Kosower et al [11] had previously reported that monobromobimane (a derivative of 1,5-diazobicyclo[3,3,0] actadiendiones) and non fluorescent compound with an electrophilic site, slowly reacted with glutathione to form fluorescent glutathione conjugate and that the reaction might be catalysed by glutathione transferase

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