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HFD impairs liver glutathione biosynthesis, vitamin D metabolism genes and genes associated with non-alcoholic fatty liver disease (NAFLD) Genes involved in the GSH biosynthesis pathway were significantly downregulated in the livers of mice fed an HFD compared to those of mice fed a healthy diet (controls) (Fig

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Indeed, polymorphisms in many of these same genes have been identified by GWAS as being associated with abnormal -cell function leading to reduced insulin synthesis and release typified in type 1 and type 2 diabetes