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Professional antigen presenting cells (macrophages and dendritic cells) and ILC can block self-reactive cells and play a crucial role in autoimmune diseases [53, 54]

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Diseases produced by defective PDC As the PDC has prime significance in intermediary metabolism, mutations in the genes encoding for PDCsubunits produce severe clinical phenotypes [40]

doi: 10.1038/s41591-021-01510-7 123 MongaVMillerBJTanasMBoukharSAllenBAndersonCet al