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362 Considering the expression of the GLP-1R in thyroid C cells and the ability of GLP-1 to stimulate calcitonin secretion through a cAMP-mediated mechanism in vitro, it is plausible that calcitonin plays a role in the alterations in bone metabolism observed in GLP-1R-treated animals

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In 1986, the biological activity of bovine GIP(1-42) and several of its fragments was characterized according to their ability to promote insulin secretion from an isolated perfused rat pancreas