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As humans do not produce TMCA, we examined the levels of non-12-OH FXR-antagonistic BA species in humans, and found that the levels of non-12-OH FXR-antagonistic BAs (HDCA and UDCA-related species) were positively correlated with T3 levels in euthyroid human study participants (Fig

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Complementing these mechanisms, recent findings demonstrate that exosome-mediated delivery of NR2F1 and its lncRNA regulator NR2F1-AS1 drives the switch from dormancy to proliferation in enzalutamide-resistant prostate cancer