Researched effects In a diet-induced-obese mouse study (Neelakantan et al., Biochemical Pharmacology, 2018), subcutaneous 5-Amino-1MQ (20 mg/kg, three times daily, roughly 11 days) produced about 5.1% body-weight loss versus continued weight gain in untreated controls, roughly 35% less epididymal white fat mass, smaller adipocytes, lower plasma cholesterol, and improved glucose tolerance, with no reported change in food intake and no observed adverse effects in the mice
An increase in the Akkermansia spp population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice (in Eng)
89 , 693S696S (2009)
Whether that multiple is justified depends entirely on whether the research question requires glucagon receptor engagement or whether the 4.3 percentage point weight loss advantage over tirzepatide (24.2% vs 20.9%) is scientifically meaningful for the study design
Plus, there are potential side effects to think about, and it's super important to get these from a qualified healthcare provider
Caloric intake should match goals, whether building muscle or recomposition
