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Paradoxically, the VD catabolic pathway mediated by CYP24A1a mitochondrial enzyme responsible for 24-hydroxylation of both 25(OH)D and 1,25(OH)2Dappears to be synergistically up-regulated by classical EIASMs [152]

Later meta-analyses also report small but significant reductions in body weight, BMI or fat mass, with effects more relevant in overweight or obese populations

They play a vital role in developing drugs with improved efficacy and fewer side effects in comparatively less time than conventional methods, allowing organizations to save time and costs

Gut microbiome and colon cancer: role of bacterial metabolites and their molecular targets in the host