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IGF-1 LR3 has a 13-amino acid N-terminal extension plus an arginine substitution at position 3, totaling 83 amino acids

Hauge C, Breitschaft A, Hartoft-Nielsen ML, Jensen S, Baekdal TA

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The researchers found that the risk for a primary outcome event (major kidney disease events, a composite of the onset of kidney failure, at least a 50 percent reduction in the estimated glomerular filtration rate from baseline, or death from kidney-related or cardiovascular causes) was significantly lower in the semaglutide group (331 versus 410 first events

PMID: 85 SiskindDHahnMCorrellCUFink-JensenARussellAWBakNet al