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More than likely the dates are there to cover producers back in case of reaction

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PMID 18823031 Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS

Its not just the shoulder that suffers

For now, indirect metabolic biomarkers remain the primary feedback mechanism

Nausea is the most frequently reported adverse effect, potentially affecting thirty to forty percent of patients at some point during treatment, though the intensity typically diminishes over time as tolerance develops