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As the first study to examine in detail the effects of GLP-1R agonists in a pre-clinical model of lipodystrophy, we provide a valuable basis for future patient studies to ultimately relieve the suffering of these patients

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GLP-1R knockdown To knockdown the expression of the GLP-1R in the LH, a short hairpin RNA (shRNA) targeting GLP-1R transcripts was used (for details, see Schimdt et al