Although technically not an amino acid (but a quaternary amine, and a metabolite of two amino acids, lysine and methionine), it not only helps us metabolize fats, proteins, and carbohydrates properly, but also functions as an antioxidant and detoxifying agent
Consistent with the effects in rat PSCs, high glucose and TGF1 levels enhanced the proliferation and decreased the apoptosis of PSCs in the LG group, whereas GSH and SB431542 prevented the effects induced by high glucose
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This is consistent with our previous study [14] in which lysosomotropic compounds were shown to decrease Lysotracker staining, indicating pH increase in the lysosomes with the compound treatment since Lysotracker requires low pH in order to accumulate in the organelles
