Patients taking GLP-1 receptor agonists such as semaglutide face an important decision when surgery is scheduled: whether to continue, pause, or adjust their medication regimen
Only certain oral formulations are FDA-approved (for example, Rybelsus for diabetes), and many oral products sold as drops are compounded, not FDA-approved, and lack the clinical testing required to confirm safety and dose
10.1016/j.brainres.2010.03.059 49 RodriguezJ
The dual actions of GLP-1 RAs, namely, the promotion of insulin secretion and the inhibition of glucagon release, exert a significant influence on the plasma ratio of these hormones, thereby contributing to the maintenance of glucose homeostasis in the body
JAMA Internal medicine, 184 (11), 13141323
Key GLP-1 Weight Loss Drug Market Segments By Drug Class Dual GIP/GLP-1 Receptor Agonists (Tirzepatide and pipeline GIP/GLP-1 molecules) Injectable GLP-1 Receptor Agonist Monoagonists (Semaglutide Wegovy and Ozempic branded portfolio) Oral GLP-1 Formulations (Oral Semaglutide, Orforglipron, Danuglipron, GSBR-1290 small molecule) Liraglutide and Legacy Injectable GLP-1 Receptor Agonists (Saxenda, Victoza) Triple Agonists and Amylin Combination Pipeline Therapies (Retatrutide, CagriSema, MariTide) By Route of Administration Subcutaneous Injectable Weekly Autoinjector (Primary Commercial Format across GLP-1 Market) Oral Small Molecule GLP-1 Receptor Agonists (Non-Peptide Tablet Formulations) Oral Peptide Tablet Formulations (Rybelsus and Successor Obesity-Labeled Oral GLP-1 Molecules) Daily Subcutaneous Injectable (Liraglutide Legacy Delivery Format) Extended-Release Implantable and Depot Formulations (Late-Stage GLP-1 Pipeline) By Application and Indication Obesity and Chronic Weight Management (Primary Commercial GLP-1 Market Indication) Type 2 Diabetes with Obesity Comorbidity (Metabolic Dual-Indication Prescribing) Cardiovascular Risk Reduction and MACE Prevention (Post-SELECT Trial GLP-1 Expansion) Metabolic Dysfunction-Associated Steatohepatitis MASH Treatment (Semaglutide Approved March 2024 ) Obstructive Sleep Apnea OSA Treatment (Tirzepatide FDA Approved November 2025 ) Adolescent Obesity Management (Wegovy Approved for Age 12 and Above June 2023 ) By Distribution Channel Specialty Pharmacy with Obesity Management Program Enrollment and Adherence Infrastructure Retail Chain Pharmacy (CVS, Walgreens, Rite Aid with GLP-1 access and refill management) Hospital and Institutional Outpatient Pharmacy Telehealth and Online Pharmacy Platforms (Hims and Hers, Ro, Amazon Clinic GLP-1 programs) Direct-to-Patient Manufacturer Access Programs (NovoCare, Lilly Cares Foundation) By Geography North America (United States and Canada GLP-1 Weight Loss Drug Market) Europe (European Union, United Kingdom, Germany, France, Italy, Spain, Nordic Countries) Asia-Pacific (Japan, China, Australia, South Korea, India, Singapore GLP-1 Markets) Latin America (Brazil, Mexico, Argentina, Colombia Regional Obesity Drug Market) Middle East and Africa (Saudi Arabia, United Arab Emirates, Israel, South Africa)
