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Reason: Too much caffeine increases cortisol and encourages oxidative activity, which weakens antioxidant action

Fretham SJ, Caito S, Martinez-Finley EJ, Aschner M (2012) Mechanisms and modifiers of methylmercury-induced neurotoxicity

The GSH/GSSG ratio and the activities of AsA-GSH cycle enzymes were also increased (Hasanuzzaman and Fujita 2011)

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[DOI] [PubMed] [Google Scholar] 278.Johansson J.O., Egberg N., Asplund-Carlson A., Carlson L.A