Both pathways are dependent on the cellular levels of the SAM molecule, which is the most important regulator of homocysteine metabolism
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Estrogen was also shown to play a crucial role in controlling oxidative stress, a major contributor to impaired wound healing, by increasing the production of antioxidants, such as superoxide dismutase (SOD), and promoting B-cell lymphoma 2 (BCL2) expression, via activation of the nuclear factor erythroid 2-related factor (NRF2) (Kanda and Watanabe, 2003
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For those who have lost a significant amount of weight or gone through pregnancy, stretched abdominal skin can be a problem