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Katsuyoshi Matsuoka, Associate Professor of the Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, for reviewing the manuscript

Simultaneously, the IRAK-TRAF6 complex activates mitogen-activated protein kinase kinase (MKK) cascades, thus leading to activation of activator protein 1 (AP-1), which is another critical transcription factor in inflammation (50)

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[53] Four additional trials (NCT03131687, NCT03311724, NCT03861052, and NCT03861039) were included in the safety evaluation, for a total of 7,769 adult participants with type 2 diabetes

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