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Dysesthesia The TRIUMPH-4 trial data revealed a notable safety signal: dysesthesia (abnormal sensations like tingling, burning, or numbness) was reported in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose of retatrutide

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Approach Extended On-cycle 5-6 weeks Off-cycle 6 weeks minimum Best for Used only after prior cycles confirmed glucose tolerance