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We adopted a male-only design in this preliminary mechanistic investigation to reduce endocrine-related variability associated with the estrous cycle and estrogen, which can modulate microglial activation and neuroinflammatory responses, thereby facilitating more stable identification of gutbrain inflammatory signaling and glial lipotoxic mechanisms following PBAT-MPs exposure

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Tirzepatide is given to patients with type 2 diabetes after meals to stimulate insulin during both phases of its secretion and concurrently suppresses glucagon release, decreasing blood glucose levels [101]

Besides recruitment and retention, a company may see GLP-1s as a path to lower its costs in the long run because weight loss generally improves health and could result in fewer and less expensive claims later