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Why its different Unlike semaglutide, which targets only GLP-1, tirzepatide works on both GLP-1 and GIP receptors

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Research from the STEP trials (semaglutide) and SURMOUNT trials (tirzepatide) demonstrates that GLP-1 agonists produce 1522% body weight loss in people with obesity, significantly outperforming older weight loss medications

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Practically, this means the peptides distribution and the coppers ultimate fate are dominated by whole-body copper homeostasis hepatic uptake, biliary excretion (the principal route by which the body eliminates excess copper), and the binding capacity of plasma proteins rather than by the peptide behaving as an independent, freely distributing drug