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Ethics declarations Ethics Approval Waived for narrative review Non-applicable

Self-administration of subcutaneous injections is straightforward

When tirzepatide is added, it creates additional metabolic signaling that requires careful medical supervision to prevent compounding effects

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Informed consent was obtained from all the subjects prior to participation in the study

Furthermore, mouse xenograft experiments showed increased IGF-1R prosphorylation in CD45 /CD24 /CD44 + breast cancer stem cell (BCSC), while activation of the PI3K/AKT/mTOR pathway facilitated BCSC maintenance and increased their EMT phenotype indicating a regulatory role for the IGF-1R pathway in BrCa stem/progenitor cells [93]