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This is normal and does not indicate the compounds have stopped working

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Vitamin B12 deficiency can also cause symptoms that affect the brain and nervous system (neurologic symptoms), including: Numbness Muscle weakness Mental health problems, ranging from mild depression or anxiety to confusion and dementia Balance and coordination issues Needles and pins Incontinence What is the best form of vitamin B12 to take

This research was supported by grants from the National Natural Science Foundation of China (32388101 and 32250001 to D.X., 32425011 and 32488302 to J.Y.), National Key R&D Program of China (2022YFD1400800 and 2021YFA1300400 to D.X.), China Postdoctoral Science Foundation (2020M670286 to Y.Y.), Postdoctoral Fellowship of Tsinghua-Peking Joint Center for Life Sciences