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most patients lose 510% of baseline weight Months 612: Peak weight loss typically occurs, with some patients losing 1015% or more of initial body weight in clinical trials, particularly on higher-efficacy agents like semaglutide 2

Fraterman, I

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For each, we favor low starting doses, short cycles (often 1014 days for an initial trial), and careful symptom monitoring

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6.6%) withdrawing from clinical trials for the following reasons: adverse reactions, logistical barriers such as not being able to attend trials, or discomfort related to interventions such as lumbar punctures or sinus irritation (Table 3)