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Dose titration is important because retatrutide can cause gastrointestinal side effects, especially when doses are increased too quickly

One study found that after stopping tirzepatide, nearly 7 out of 10 users regained more than 5% of the weight theyd lost within a year, moving closer to their original weight

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Primary prevention measures have been suggested previously

These treatments are especially beneficial for men who need help with appetite regulation, blood sugar control, and overall metabolic function

Provider assessment should consider both mechanism fit and individual metabolic markers