To restore LepRb signaling specifically in PPG neurons, LepRb TB/TB mice were crossed with GCG-Cre mice (resulting in GCG-Cre::LepRb TB/TB mice) and the density of GLP-1 immunoreactive fibers was measured in the PVH
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There is substantial evidence that the expression of SOCS3 protein increases with aging in several cells/tissues, such as rat myocardium [162], hypothalamus [163], and human blood mononuclear cells [164] as well as human sarcopenic skeletal muscles [165] and the brains of Alzheimers patients [166]
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Cell Death Dis 12(7):671 Herting MM, Bottenhorn KL, Cotter DL (2024) Outdoor air pollution and brain development in childhood and adolescence
GLP-1 receptor agonists mimic GLP-1, lowering blood glucose by stimulating insulin secretion, slowing gastric emptying, and decreasing glucagon release 13
