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In addition, proteomic analysis confirmed upregulation of collagen type I and decorin, consistent with dermal remodeling activity

In particular, ChAT expression is induced by the Th2-associated master regulator GATA3 and the suppression of RE-1 silencing transcription factor (REST)-mediated methylation of the ChAT promoter (124) ( Figure 3 )

It also earned five Oscar nominations, which meant that the ceremony last March marked Cakarels first trip to the Academy Awards

The New England Journal of Medicine, 385 (6), 503515

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