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Even though animal models show benefits from melatonin supplementation on depressive-like behavior, clinical evidence is inconsistent vis--vis prophylactic or therapeutic benefits of melatonin or melatonin agonists in depression

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Frontiers in Cell and Developmental Biology, 12 , 1464815

Methods Cell viability assay TSPCs were isolated from tendon tissues of three 8-week old male Sprague-Dawley (SD) rats as three independent biological samples and identified for their cell surface marker expression and multi-directional differentiation potential, as our previous study [33, 53]