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These findings are mostly applicable to individuals on metformin-based background therapy, while further trial data are required to determine whether the salutary metabolic effects of tirzepatide translate to long-term cardiovascular benefits

Ong et al., 2017

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63 Furthermore, potential side effects like nausea or vomiting can lead to fluid loss, and dehydration can worsen common issues like constipation, fatigue, and headaches

Treatment with LY2409021, a glucagon receptor antagonist, increases liver fat in patients with type 2 diabetes