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Example 8 Coupling of the peptide resin fragment, PEG-PEG- -Glu-Octadecanedioic Acid mono-tert-butyl ester Fmoc-PEG-OH, Fmoc-Glu(OH)-OtBu and octadecanedioic acid mono-tert-butyl ester were sequentially coupled by conventional amino acid coupling

After undergoing magnetic stirring for 8 h at room temperature, mPEG 5000 -OH (0.68 g, 0.13 mmol) was introduced into the reaction system

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Keller J, Ringseis R, Fau - Koc A, Koc A, Fau - Lukas I, Lukas I, Fau - Kluge H, Kluge H, Fau - Eder K, Eder K