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Long-term ultrastructural indices of lead intoxication in pulmonary tissue of the rat

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Side effects are typically mild and temporary, such as slight soreness at the injection site

Ann N Y Acad Sci (2010) 1199:5268

The subsequent ASPEN Phase III trial confirmed these findings, with brensocatib reducing annualized exacerbation rates by 21% (10 mg) and 19% (25 mg) compared to placebo (adjusted p = 0.004 and p = 0.005, respectively)

While glutathione linkage to PNIPAm was confirmed, a detailed validation of the interaction with GST tagged proteins was not presented