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2.2.3 Key regulatory networks The tumor suppressor p53 can transcriptionally repress SLC7A11 expression, diminishing cystine uptake, curtailing GSH synthesis, and thereby promoting ferroptosis ( Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating redox homeostasis

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Blunden S.L., Milte C.M., Sinn N

Because of its important activity on platelet aggregation, it would be dangerous to exceed these doses without risk of bleeding or hemorrhage

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For some patients who benefit from gradual dose transitions , this inflexibility is a real limitation