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Stress significantly worsens sleep quality, makes you less motivated to exercise, and leads you to overindulge on comfort foods, which tend to be high in calories, fat, and sugar

By contrast, the long-acting GLP-1RAs (semaglutide [ t 1/2 of 5 days] administered subcutaneously once-weekly or as a once-daily oral formulation and dulaglutide [ t 1/2 of 7 days] administered subcutaneously once-weekly) causing continuous exposure and activation of the GLP-1 receptor resulting in short-lasting effects on upper gastrointestinal motility (31) superseded by subsequent development of tachyphylaxis (16)

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