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Ongoing studies continue to monitor for potential rare side effects, including effects on the pancreas, thyroid, and cardiovascular system

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Nausea is typically most pronounced during dose initiation and escalation, generally improving over 24 weeks as physiologic adaptation occurs

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Combined exposure to ethanol and palmitoleic acid (POA) increases intracellular and mitochondrial ROS in AR42J pancreatic cells that results in a significant increase in the necroptosis mediator receptor-interacting protein and mixed lineage kinase domain-like pseudokinase