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[DOI] [PubMed] [Google Scholar] 33.Macchi M.M., Bruce J.N

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This live-attenuated vaccine elicits both humoral and cell-mediated immunity, producing long-lasting protection after two doses

Over the following weeks most people notice steadier energy and fewer afternoon crashes first (weeks 12), then early fat loss around the midsection with workouts feeling more productive (weeks 24), then measurable body-fat reduction and better endurance and recovery (weeks 48), with metabolic markers like glucose and triglycerides often improving by week 8+

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Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man