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Moreover, we confirmed the oxidizing influence of Erv1 (and the respiratory chain and oxygen) on Mia40, and we found a reducing influence of cytosolic Glr1 and thus of the glutathione pool in the IMS on the Mia40 redox state

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PLoS One 2018

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In contrast, semaglutide, despite its widespread clinical use for glycemic control and weight loss, showed minimal interaction with neurodegenerative pathways within the DM2-AD comorbidity network, suggesting that its metabolic benefits may not translate into AD risk reduction through core disease-associated mechanisms

The use of drugs like Ozempic, Wegovy and Zepbound in people with type 1 diabetes has risen sharply over the past decade, a new study finds, even though theres little information on the drugs safety and effectiveness for the condition