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New England Journal of Medicine, 384(11), 989-1002

Indications and Usage for Nascobal NASCOBAL is indicated for: Vitamin B12 maintenance therapy in adult patients with pernicious anemia who are in remission following intramuscular vitamin B12 therapy and who have no nervous system involvement Treatment of adult patients with dietary, drug-induced, or malabsorption-related vitamin B12 deficiency not due to pernicious anemia Prevention of vitamin B12 deficiency in adult patients with vitamin B12 requirements in excess of normal Limitations of Use NASCOBAL should not be used for the vitamin B12 absorption test (Schilling test)

Chromatographic Resolution The method should separate both intended peptides and detectable related substances

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This observed process, lasting typically 4-8 weeks in some research, is an important consideration when evaluating its effects

The deconjugation of BAs is of great importance because it can counteract BA toxicity and promote secondary BA production in the colon