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Although the effect of ALC on cholinergic neurotransmission has not been clearly documented, both postsynaptic 12 and presynaptic 13 mechanism is proposed

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IDH1 is a cytosolic enzyme that metabolizes isocitrate to -KG to generate cytosolic NADPH

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232 In addition to HIF-1, SIRT1 regulates other important factors, such as p53, c-Myc, FOXO3, E2F1, BAX, and NF-B