Additionally, Tesofensine also affects the reward pathways in the brain, making it less rewarding to eat food, leading to further decrease in food intake
Perhaps a combination of these mechanisms plays a role in their cardiac protective effects
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Oral administration faces hepatic first-pass metabolism, reducing bioavailability to approximately 4050% of subcutaneous routes, but offers convenience for longer-term studies where daily injections create compliance challenges
10.1126/scitranslmed.3007811 168 RashighiM.HarrisJ