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A wearable, rapidly manufacturable, stability-enhancing microneedle patch for closed-loop diabetes management

2001 Jan;19(1):49-51

The mechanisms of DSPN are not fully understood but involve downstream injurious pathways associated with hyperglycaemia, dyslipidaemia and microvascular disease leading to neuronal inflammation, oxidative stress, mitochondrial dysfunction and cell death

The severity of each can range from mild to extremely disruptive to daily living

Overall, accumulating evidence suggests that paternal diabetes can program offspring metabolic outcomes through stable, heritable epigenetic modifications

36 , 130143 e135 (2024)